Reference Intervals for Common Laboratory Tests in Melanesian Children

Laboratory Reference Intervals in Africa

Prerequisites for use of common reference intervals.

The theory of reference values was developed more than 30 years ago, but its application in most clinical laboratories is still incomplete today. This is for several reasons, the most relevant ones being the lack of standardisation of the analytical methods, resulting in method-dependent values, and the difficulty in recruiting the proper number of reference subjects for establishment of refere...

eJIFCC Special Issue on Laboratory Reference Intervals

Recent decades have witnessed a tremendous increase in the number of new diagnostic methods and the introduction of many emerging new biomarkers in clinical diagnostic laboratories. The utility of biomarkers as screening and diagnostic tools is limited by many factors, such as sensitivity, specificity and predictive values. Another critical factor, not always carefully considered, is the availa...

Interference in laboratory tests

Interference in clinical laboratory testing can create discrepancies in test results which can lead to patient harm.  In clinical chemistry, interference is defined as a cause of medically significant difference in the measurand test result due to another component or property of the sample. Interference by endogenous and exogenous substances with assays for clinical analytes is a common prob...

Reference intervals for nine tests on the RA-1000.

1984 CLINICAL CHEMISTRY, Vol. 32, No. 10, 1986 ing final concentrations of 92 mmol of Mn and 1.3 g of heparin per liter was 101.3% (SD 3.2%). It has been generalized in the literature that the use of hep-Mn as an apo-B precipitant adversely affects enzymatic cholesterol reagents. However, these claims are based on the report by Steele et al. or are unquoted. As shown here, hepMn does not affect...